Nobel Prize in Physiology/Medicine 1991
was awarded to Dr. Neher & Sakmann
for their discoveries concerning the function of single ions channels in cells
Below is a 3 page summary of the discoveries

In Brief:  they discovered that all cells open and close their cell wall 'doors' with ions. 
And if they are not present, then the doors to nutrients and the doors to waste removal are closed.
If there are not enough ions to go around, then some (or many) cells suffer. 
Think garbage strike:  no trucks picking up trash, it sits in the streets and rots/smells.

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